TRICHY BIOMEDICAL V SEM SYLLABUS

ANNA UNIVERSITY TIRUCHIRAPPALLI TIRUCHIRAPPALLI - 620 024 AFFILIATED INSTITUTIONS
Regulations 2008 Curriculum B.E. BIOMEDICAL ENGINEERING
SEMESTER III
S.No. Subject Code Subject L T P C
Theory
1 Transforms and Partial Differential Equations 3 1 0 4
2 Medical Physics 3 0 0 3
3 Signals and Systems 3 1 0 4
4 Sensors and Measurements 3 1 0 4
5 Electronic Circuits 3 1 0 4
6 Biochemistry 3 0 0 3
7 Anatomy and Human Physiology 3 0 0 3
Practical
8 Biochemistry and Human Physiology Laboratory 0 0 4 2
9 Electronic Circuits Laboratory 0 0 3 2
Total 29
ANNA UNIVERSITY TIRUCHIRAPPALLI TIRUCHIRAPPALLI - 620 024
AFFILIATED INSTITUTIONS Regulations 2008
Syllabus B.E. Bio Medical Engineering
SEMESTER III
TRANSFORMS AND PARTIAL DIFFERENTIAL EQUATIONS
(Common to all branches of BE / B.Tech Programmes)
L T P C
3 10 4
UNIT I FOURIER SERIES 9
Dirichlet's Conditions - General Fourier Series - Odd and Even Functions - Half Range Sine Series - Half Range Cosine Series - Complex Form of Fourier Series - Parseval's Identity - Harmonic Analysis.
UNIT II FOURIER TRANSFORMS 9
Fourier Integral Theorem (Without Proof) - Fourier Transform Pair - Sine and Cosine Transforms - Properties - Transforms of Simple Functions - Convolution Theorem - Parseval's Identity.
UNIT III PARTIAL DIFFERENTIAL EQUATIONS 9
Formation of Partial Differential Equations - Lagrange's Linear Equation - Solutions of Standard Types of First Order Partial Differential Equations - Linear Partial Differential Equations of Second and Higher Order with Constant Coefficients.
UNIT IV APPLICATIONS OF PARTIAL DIFFERENTIAL EQUATIONS 9
Solutions of One Dimensional Wave Equation - One Dimensional Equation of Heat Conduction - Steady State Solution of Two-Dimensional Equation of Heat Conduction (Insulated Edges Excluded) - Fourier Series Solutions in Cartesian Coordinates.
UNIT V Z -TRANSFORMS AND DIFFERENCE EQUATIONS 9
Z-Transforms - Elementary Properties - Inverse Z-Transform - Convolution Theorem -Formation of Difference Equations - Solution of Difference Equations Using Z-Transform.
L: 45 T: 15 Total: 60
TEXT BOOK
1. Grewal B. S, "Higher Engineering Mathematics", Fourth Edition, Khanna Publishers, Delhi, 2007.
REFERENCES
1. Bali N. P and Manish Goyal, "A Textbook of Engineering Mathematics", Seventh Edition, Laxmi Publications Private Ltd, 2008.
2. Ramana B. V, "Higher Engineering Mathematics'", TMH Publishing Company
Limited, New Delhi, 2nd edition, 2008.
3. Glyn James, "Advanced Modern Engineering Mathematics", Third Edition, Pearson Education, 2008.
4. Erwin Kreyszig, "Advanced Engineering Mathematics", Eighth Edition, Wiley
India, 2008.
MEDICAL PHYSICS
LTP C 3 0 0 3
UNIT I ELECTROMAGNETIC SPECTRUM AND ITS MEDICAL
APPLICATIONS 9
Light - Physics of Light - Intensity of Light - Limits of Vision and Color Vision -Sound - Physics of Sound - Normal Sound Levels - Ultrasound Fundamentals -Generation of Ultrasound (Ultrasound Transducer) - Interaction of Ultrasound With Materials - Reflection and Refraction - Absorption and Scattering - Non-Ionizing Electromagnetic Radiation Tissue as a Leaky Dielectric - Relaxation Processes -Overview of Non - Ionizing Radiation Effects - Low Frequency Effect - High Frequency Effect.
UNIT II RADIOACTIVE AND ITS TYPES 9
Radioactive Decay - Spontaneous Emission - Isometric Transition - Gamma Ray Emission - Alpha - Beta - Positron Decay - Electron Capture Principles of Nuclear Physics - Natural Radioactivity - Decay Series - Half Life Period - Type of Radiation and their Applications - Production of Radio Nuclides - Cyclotron Produced Radionuclide - Reactor Produced Radionuclide - Fission And Electron Capture Reaction - Radionuclide Generator - Milking Process - Linear Accelerator - Radionuclide Used in Medicine and Technology.
UNIT III INTERACTION OF RADIATION WITH MATTER 9
Interaction of Charged Particles with Matter - Specific Ionization - Linear Energy Transfer Range - Bremsstrahlung - Annihilation Interaction of Gamma Radiations with Matter - Photoelectric Effect - Compton Scattering - Pair Production - Attenuation of Gamma Radiation - Interaction of Neuron with Matter.
UNIT IV PHYSICS OF CARDIOPULMONARY SYSTEM 9
The Airways - Blood And Lung Interaction - Measurement of Lung Volume - Pressure Air Flow Volume Relationships of Lungs - Physics of Alveoli - The Breathing Mechanism - Major Components of Cardiovascular System - O2 and CO2 exchange in the Capillary System - Physical Activity of Heart - Transmural Pressure - Bernolli's Principles Applied to Cardiovascular System - Blood Flow - Laminar and Turbulent.
UNIT V RADIATION EFFECTS 9
Acute Radiation Effects - The Concept of LD 50 - Radiation Syndromes - Central Nervous System Syndrome - Gastro-Intestinal Syndrome - Bone Marrow Syndrome -Delayed Effects of Radiation - Stochastic and Deterministic Effects - Late deterministic effect in different organs and tissues.
Total: 45
TEXT BOOKS
1. B. H. Brown, P. V. Law Ford, R. H. Small Wood , D. R. Hrodse , D. C. Barber,
"Medical Physics and Biomedical Engineering', CRC Press,3rd edition 1999.
2. Gopal B. Saha, "Physics and Radiobiology of Nuclear Medicine" Springer, 3 rd
Edition, 2006.
REFERENCES
1. John R. Cameron and James G. Skofronick, "Medical Physics", John-Wiley & Sons,3rd edition, 1978.
2. R F Farr and P J Allisy Roberts, "Physics for Medical Imaging', Saunders, 3rd
edition,1997.
3. P. Uma Devi, A. Nagarathnam, B. S. Satish Rao, "Introduction to Radiation Biology", B. I. Churchill Livingstone Pvt Ltd,3rd edition, 2000.
4. S. Webb, "The Physics of Medical Imaging', Taylor and Francis, 4th edition,1988.
SIGNALS AND SYSTEMS
L T P C
3 10 4
UNIT I CLASSIFICATION OF SIGNALS AND SYSTEMS 9
Continuous Time Signals (CT Signals) - Discrete Time Signals (DT Signals) - Step -Ramp - Pulse - Impulse - Exponential - Classification of CT and DT Signals - Periodic and Aperiodic - Random Signals - CT Systems and DT Systems - Basic Properties of Systems - Linear Time Invariant Systems and Properties.
UNIT II ANALYSIS OF CONTINUOUS TIME SIGNALS 9
Fourier Series Analysis - Spectrum of C .T. Signals - Fourier Transform and Laplace Transform in Signal Analysis.
UNIT III LINEAR TIME INVARIANT - CONTINUOUS TIME SYSTEMS 9
Differential Equation - Block Diagram Representation - Impulse Response - Convolution Integral - Frequency Response - Fourier and Laplace Transforms in Analysis - State Variable Equations and Matrix Representation of Systems.
UNIT IV ANALYSIS OF DISCRETE TIME SIGNALS 9
Sampling of CT Signals and Aliasing - DTFT and Properties - Z-Transform and Properties of Z-Transform.
UNIT V LINEAR TIME INVARIANT - DISCRETE TIME SYSTEMS 9
Difference Equations - Block Diagram Representation - Impulse Response - Convolution Sum - LTI Systems Analysis using DTFT and Z-Transforms - State Variable Equations and Matrix Representation of Systems.
L: 45 T: 15 Total: 60
TEXT BOOKS
1. Allan V Oppenheim, S. Wilsky and S. H Nawab, "Signals and Systems'", Pearson
Education, 8th edition,2007.
2. P.Ramakrishna Rao , "Signals and Systems", TMH,5th edition,2008
REFERENCES
1. Simon Haykins and Barry Van Veen, "Signals and Systems", John Wiley and Sons , 2nd edition,2004.
2. Robert A. Gabel and Richard A. Roberts, "Signals and Linear Systems", John
Wiley, Third Edition, 1987.
3. Rodger E. Ziemer, William H. Tranter, D. Ronald Fannin, "Signals & Systems", Fourth Edition, Pearson Education, 2002.
4. C.T.Chen, "Linear System Theory and Design", Holt, Rinehart & Winston,Inc.,Newyork,N.Y.2nd edition ,1984.
SENSORS AND MEASUREMENTS
LTP C
3 1 0 4
UNIT I SCIENCE OF MEASUREMENTS 8
Measurement System - Instrumentation - Classification and Characteristics of Transducers - Static and Dynamic - Errors in Measurements - Calibration - Primary and Secondary Standards.
UNIT II DISPLACEMENT, PRESSURE, TEMPERATURE SENSORS 10
Strain Gauge: Gauge Factor - Sensing Elements - Configuration - Unbounded Strain Gage - Biomedical Applications - Strain Gauge as Displacement & Pressure Transducers
- Force Summing Devices - Capacitive Transducer - Inductive Transducer - Linear Variable Differential Transducer - Passive Types - RTD Materials & Range - Relative Resistance Vs. Temperature Characteristics - Thermistor Characteristics - Biomedical Applications of Temperature Sensors - Active Type: Thermocouple - Characteristics.
UNIT III PHOTOELECTRIC AND PIEZO ELECTRIC SENSORS 9
Phototube - Photo Multiplier Tube - Photovoltaic - Photoconductive Cells - Photo Diodes - Phototransistor - Comparison of Photoelectric Transducers - Spectro-Photometric applications of Photo Electric Transducers - Piezoelectric Active Transducer and Biomedical applications as Pressure & Ultrasound Transducer.
UNIT IV SIGNAL CONDITIONING & SIGNAL ANALYSER 9
AC and DC Bridges - Wheat Stone Bridge - Kelvin - Maxwell - Hay - Schering - Pre¬Amplifier - Impedance Matching Circuits - Isolation Amplifier - Spectrum Analyzer.
UNIT V DISPLAY AND RECORDING DEVICES 9
Digital Voltmeter - Multi Meter - CRO - Block Diagram, CRT - Vertical & Horizontal Deflection System - DSO - LCD Monitor - PMMC Writing Systems - Servo Recorders
- Photographic Recorder - Magnetic Tape Recorder - X-Y Recorder - Thermal Recorder.
L: 45 T: 15 Total: 60
TEXT BOOKS
1. L. A Geddas, L. E.Baker, "Principles of Applied Biomedical Instrumentation", 3rd
Edition, John Wiley and Sons, 1989.
2. Albert D.Helfrick, William D. Cooper "Modern Electronic Instrumentation and Measurement Techniques", Prentice Hall of India,4th edition, 2007.
REFERENCES
1. Ernest O. Doeblin, Dhanesh N. Manik, "Measuremet Systems, Application and Design", 5th Edition, Tata McGraw-Hill, 2007.
2. Khandpur R. S., "Handbook of Biomedical Instrumentation", Tata McGraw-Hill,
New Delhi, 2nd edition,2007.
3. Leslie Cromwell, "Biomedical Instrumentation and Measurement", Prentice Hall of India, New Delhi, 3rd edition,2007.
4. John.G. Webster, "Medical Instrumentation Application and Design", John
Wiley and sons, New York,3rd edition 2004.
ELECTRONIC CIRCUITS
L T PC 3 1 0 4
UNIT I DIODE APPLICATIONS AND TRANSISTOR BIASING 9
Rectifiers - HWR - FWR - Bridge Rectifier with and without Capacitor and Pie Filter. Clipper - Clampers - Voltage Multiplier Circuits - Operating Point of the Bi-Polar Junction Transistor - Fixed Bias Circuit - Transistor on Saturation - Emitter Stabilized Bias Circuit - Voltage Divider Bias - Transistors Switching Network - Trouble Shooting the Transistor (In Circuit Testing) - Practical Applications - Biasing the FET Transistors
- CMOS Devices - MOSFET Handling.
UNIT II SMALL SIGNAL AMPLIFIERS 9
Two Port Network - H-Parameter Model - Small Signal Analysis of BJT (CE and CC Configurations Only) - High Frequency Model of BJT - (CE Configuration Only) -Small Signal Analysis of JFET (CS Configuration Only) - Frequency Response of BJT and FET.
UNIT III FEEDBACK AMPLIFIER AND OSCILLATORS 9
Basic of Feedback System (Block Diagram Approach) - Types of Feedback Amplifier -Basic Principles of Oscillator - Audio Oscillators - RC Phase Shift and Wein Bridge Oscillator - RF Oscillators - Heartly and Collpit Oscillator - Crystal Oscillator -Multivibrators.
UNIT IV POWER AMPLIFIERS 9
Definition - Types of Power Amplifiers - Class A (Series Fed - Transformer Coupled )-Class B Amplifier - Class-B Push-Pull Amplifier - Complimentary Symmetry Type -Class-C Amplifier - Heat Sink .
UNIT V VOLTAGE REGULATIONS 9
Shunt Voltage Regulator - Series Voltage Regulator - Current Limiting - Feedback Technique - SMPS (Block Diagram Approach) - DC to DC Converter - Three Terminal IC Regulators (78XX And 79XX).
L : 45 T : 15 Total: 60
TEXT BOOK
1. Robert L. Boylestad, Louis Nashelsky, "Electronic Devices and Circuit Theory" , Prentice Hall of India , 6th edition,2004.
REFERENCES
1. David A. Bell, "Electronic Devices and Circuits", Oxford University press,2008.
2. Millman Haykins, "Electronic Devices and Circuits", 2nd Edition, Tata McGraw
Hill, 2007.
BIOCHEMISTRY
L T PC
3 0 0 3
UNIT I BIOMOLECULE STRUCTRES 6
Basics of Biochemistry - Biomolecules - Structure of Water & its Importance -Important Noncovalent Forces - Hydrogen Bonds - Electrostatic - Hydrophobic & Vanderwaals Forces - Acid - Base & Buffers - Ph - Henderson Hasselbalch Equation. Biological Buffers and their Significance - Principle of Viscosity - Surface Tension -Adsorption - Diffusion - Osmosis & their Applications in Biological Systems.
UNIT II STUDY OF AMINO ACIDS, LIPIDS AND NUCLIC ACIDS 9
Classification - Structure & Properties of Carbohydrates - Mono - Di - Oligo & Polysaccharides - Classification - Structure & Properties of Amino Acids & Proteins -Classification - Structure & Properties of Lipids - Simple Lipids - Phospholipids -Glycolipids & Steroids - Transport of Lipids: Lipoproteins Structure & Functions of
Nucleic Acids - Nucleosides - Nucleotides - Cyclic AMP - Cyclic GMP - ATP - GTP - DNA & RNA.
UNIT III ENZYMES AND METABOLISM 12
Classification of Enzymes - Chemical Nature - Active Site - Specificity of Enzyme Catalyzed Reactions - Regulation : Feedback - Allosteric - Covalent Modification -Hormonal Regulation - Co-enzymes - Assay of Enzymes - Enzymes in Clinical Diagnosis of Diseases - Basics of Metabolism - Carbohydrate Metabolism - Glycolysis Lipid Metabolism - Fatty Acid - Beta Oxidation - Ketogenesis and Cholesterol Metabolism - TCA Cycle - Structure of Biological Membranes - Electron Transport & Oxidative Phosphorylation.
UNIT IV FUNCTIONS OF LIVER, KIDNEY & HARMONES 9
Liver Function and Liver Function Tests - Kidney Function and Kidney Function Tests -Normal & Abnormal Constituents of Urine and their Clinical Significance - General Characteristics of Hormones - Structure - Functions & Disorders of Thyroid -Parathyroid - Pituitary - Adrenal and Pancreatic Hormones - Hormones as Chemical Messengers: General Assay of Hormones - Bio Assay - Chemical Assay & Immuno Assays.
UNIT V
ELECTROPHORESIS AND CHROMATOGRAPHY 9
Analytical Techniques: Principle and Applications of Electrophoresis - PAGE - SDS PAGE - Isoelectric Focusing - Two Dimensional Electrophoresis - Chromatography: Principle of Adsorption & Partition Chromatography - Size Exclusion - Ion Exchange & Affinity Chromatography - Spectro Photometry - Fluorimetry - Flame Photometry -Manometry - Microcalorimetry - Electrochemical Methods - Biosensors - Automation in Clinical Laboratory - Use of Radio Isotopes in Biochemistry.
Total:45
TEXT BOOKS
1. David .W. Martin, Peter .A. Mayes, Victor. W. Rodwell, "Harper'sreview of Biochemistry", LANGE Medical Publications,20th edition, 2003.
2. Keith Wilson & John Walker, "PracticalBiochemistry - Principles & Techniques" , 5th Edition, Oxford University Press, 2003.
REFERENCES
1. Trevor Palmer, " Understanding Enzymes", Ellis Horwood LTD,3rd edition.
2. Pamela C. Champe & Richard A. Harvey, "Biochemistry Lippincott's Illustrated Reviews", 3rd Edition, Lippincott-Raven Publishers, 2006.
ANATOMY AND HUMAN PHYSIOLOGY
L T PC
3 0 0 3
UNIT I STUDY OF CELLULAR SYSTEM 8
Cell - Structure and Organelles - Functions of each Component in the Cell - Cell Membrane - Transport Across Membrane - Origin of Cell Membrane Potential (Nernst and Goldman and Katz Equations) - Action Potential.
UNIT II HEMATOLOGICAL SYSTEM 9
Blood Composition - Functions of Blood - Functions of RBC - WBC types and their Functions - Blood Groups - Importance of Blood Groups - Identification of Blood Groups - Blood Flow Factors Regulating Blood Flow Such as Viscosity - Radius -Density Etc (Fahreus Lindqvist Effect, Poiseuille's Law ).
UNIT III RENAL AND RESPIRATORY SYSTEM 9
Structure of Kidney and Nephron - Mechanism of Urine - Formation and Acid Base Regulation - Dialysis - Components of Respiratory System - Oxygen and Carbon Dioxide Transport and Acid Base Regulation.
UNIT IV CARDIAC SYSTEM 9
Structure of Heart - Properties of Cardiac Muscle - Cardiac Muscle and Pacemaker Potential - Cardiac Cycle - ECG - Heart Sound - Volume and Pressure Changes and Regulation of Heart Rate.
UNIT V SENSORY SYSTEM 10
Structure of a Neuron - Synaptic Conduction - Conduction of Action Potential in Neuron Parts of Brain Cortical Localization of Functions - EEG - Simple Reflexes - Withdrawal Reflexes - Autonomic Nervous System and its Functions - Structure of Eye - Ear and Auditory and Visual Pathways.
Total: 45
TEXT BOOK th
1. Elaine N. Marieb, "Essential of Human Anatomy and Physiology", 8th Edition, Pearson Education New Delhi , 2007.
REFERENCES nd
1 William F. Ganong, "Review of Medical Physiology", 22nd Edition, Tata Mc Graw Hill, New Delhi, 2005.
2 Prof. A. K. Jain, "Text book of Physiology", 3rd Edition, Volume I and II, Avichal Publishing Company, New Delhi.
BIOCHEMISTRY AND HUMAN PHYSIOLOGY LABORATORY
L T PC
0 0 4 2
1. General tests for carbohydrates, proteins and lipids.
2. Preparation of serum and plasma from blood.
3. Estimation of blood glucose.
4. Estimation of serum cholesterol.
5. Assay of SGOT/SGPT.
6. Estimation of creatinine in urine.
7. Electrophoresis of serum proteins.
8. Separation of amino acids using thin layer chromatography.
9. ESR, PCV, MCH, MCV, MCHC, total count of RBCs and Hemoglobin estimation
10. Differential count of different WBCs and Blood group identification.
11. Ishihara chart for color blindness and Snellen's chart for myopia and hyperopia -by letters reading and ophthalmoscope to view retina.
12. Weber's and Rinnee's test for auditory conduction.
Total:45
ELECTRONIC CIRCUITS LABORATORY
LTP C 0 0 3 2
1. Rectifiers - HWR and FWR (with & without capacitor filter).
2. Zener diode as regulator.
3. Study of biasing circuits
i) Fixed bias
ii) Self bias
iii) Collector to base bias.
4. FET amplifier.
5. Differential amp - CMRR and determination of Gain.
6. Design of RC coupled amplifier.
7. Design of Voltage series feedback amplifier.
8. Design of Class A and Class B amplifier.
9. Design of RC phase shift oscillator.
10. Design of Hartley Oscillator.
11. Design of Colpitt oscillator.
12. Study of pulse shaping circuits
i) . Astable Multivibrator.
ii) . Monostable Multivibrator.
Total: 45