TRICHY Pharmaceutical V SEM SYLLABUS

ANNA UNIVERSITY TIRUCHIRAPPALLI
TIRUCHIRAPPALLI - 620 024 Regulations 2007
Curriculum
B.Tech. Pharmaceutical Technology
SEMESTER V
S.No. Subject Code Subject L T P M
Theory
1 Pharmaceutical Chemistry 3 1 0 100
2 Pharmaceutical Dosage Forms 4 0 0 100
3 Pharmacology 3 1 0 100
4 Engineering Thermodynamics 4 0 0 100
5 Chemical Reaction Engineering 4 0 0 100
6 Process Instrumentation 4 0 0 100
Practical
7 Pharmaceutical Chemistry Laboratory 0 0 3 100
8 Pharmaceutical Dosage Forms Laboratory 0 0 3 100
9 Chemical Reaction Engineering Laboratory 0 0 3 100
ANNA UNIVERSITY TIRUCHIRAPPALLI
TIRUCHIRAPPALLI - 620 024
Regulations 2007
Syllabus B.Tech. Pharmaceutical Technology
SEMESTER V
PHARMACEUTICAL CHEMISTRY
UNIT I PHYSICO-CHEMICAL PROPERTIES ON BIOLOGICAL ACTION OF
Physical properties - Optical isomers - Geometric isomers - Bioisosterism - Receptors -Occupational theory - Affinity theory.
UNIT II AUTONOMIC AND CENTRAL NERVOUS SYSTEM ACTING DRUGS
9
Structure - Synthesis - Uses - Pilocarpine - Neostigmine - Propanthallene - Salbutamol -Amphetamine - Phenoxy benzamine - Tolazoline - Thiopentone - Diazepam - Chlorpromazine -Haloperidol.
UNIT III CARDIOVASCULAR AND RESPIRATORY SYSTEM ACTING DRUGS 9
Synthesis - Uses - Digoxin - Digitoxin - Procainamide - Diltiazem - Isosorbide dinitrate -Captopril - Frusemide - Lovastatin - Clofibrate.
UNIT IV ANTIMICROBIAL AGENTS 9
Preparation - Therapeutic uses - Cephalosporine - Silver Sulphadiazine - Cotrimoxazole -Roxithromycin - Isoniazid - Pyrazinamide - Dapsone - Clofazimine - Idoxuridine - Zidovudine -Quinine - Primaquine - Cyclophosphamide - Methotrexate - Griseofulvin.
UNIT V PERIPHERAL NERVOUS SYSTEM AND GASTROINTESTINAL DRUGS 12
Structure - Synthesis - Uses - Gallamin triethiodide - Dantrolene Sodium - Ranitidine -Omeprazole - Metronidazole - Cinnarizine - Dicyclomine - Bisacodyl.
L T
3 1
P
0
DRUGS 9
L: 45 T: 15 Total: 60
TEXTBOOKS
1. Ilango, K and Valentina, P., "Text Book of Medicinal Chemistry", Vol. I, 1st Edition, Keerthi Publishers, 2007.
2. Kadam, S.S., Mahadik, K.R and Bothara, K.G., "Principles of Medicinal Chemistry", Vol. I and II, Nirali Prakashan Publications, 1997.
REFERENCES
1. Chatwal, G., "Organic Chemistry of Natural Products", Vol. I and II, 3rd Edition, Himalaya
Publishing House, 2002.
2. Wolff, M. E., "Burgers: Medicinal Chemistry", 5th Edition, Vol. I to VI, John Willy and
Sons, 2005.
3. Bentley and Driver's "Text Book of Pharmaceutical Chemistry" 8th Edition, Oxford University Press, 2002.
PHARMACEUTICAL DOSAGE FORMS
L T 4 0
P 0
UNIT I
PREFORMULATION 12
Concepts - Aqueous solubility - Partition coefficient - Dissolution - Melting point - Polymorphism - Assay development - Crystal morphology - Particle size - Powder flow properties - Compression properties - Excipient compatibility - Permeability - Stability.
Classification - Solubility - Importance of aqueous solubility - Choice of solvents - Additives used in liquid orals - Formulation - Manufacturing - Packing - Labeling and storage of solutions -Syrups - Dry syrups - Lotions - Liniments - Formulation and manufacturing of suspension -Emulsion - Evaluations of suspension - Emulsion - Physical - Chemical stability - Stability testing of suspension - Emulsion.
UNIT III SEMISOLID DOSAGE FORMS 12
Classification - Advantages - Disadvantages - Semisolid bases types - Mechanism of drug penetration - Factors influencing penetration - Selection - General formulation - Manufacturing procedure - Evaluation - Packaging - Labeling - Storage requirements of ointments - Paste - Gels.
UNIT IV PARENTERAL DOSAGE FORMS 12
Routes of administration - Official types of injections - Vehicles - Solutes - Containers - Devices -Formulation - Production - Sterilization - Packaging - Evaluations - Ophthalmic preparations -Formulation - Packaging - Storage - Official methods of evaluation.
UNIT V AEROSOLS 12
Advantage and disadvantage of aerosols - Components of aerosol package - Aerosol systems -Aerosol formulations - Selection of components - Aerosol filling - Quality control of pharmaceutical aerosol.
TEXT BOOKS
1. Aulton, M.E., "Pharmaceutics - The Science of Dosage form Design", 2nd Edition, ELBS
Publications, 2002.
2. Lachman, L and Liberman, H.A., "Theory and Practice of Industrial Pharmacy", 3rd Edition, Varghese Publishing House, 1991.
REFERENCES
1. Gennaro, A.R., "Remington: The Science and Practice of Pharmacy", 21st Edition, Vol. I and II, Lippincott Williams and Willkins, 2005.
2. Carter, S.J., "Cooper and Gunn's "Dispensing Pharmacy for Pharmaceutical Students", 12th Edition, CBS Publishers & Distributors, 1987.
3. Banker, G.S and Rhodes, C.T., "Modern Pharmaceutics", 4th Edition, Informa Health Care,
2002.
UNIT II
LIQUID DOSAGE FORMS 12
Total: 60
PHARMACOLOGY
LT P 3 10
UNIT I GENERAL PHARMACOLOGY 9
Routes of administration - Pharmacokinetics - Pharmacodynamics - Receptors - Theories of receptors - Occupational theory - Affinity theory - Mechanism of action of drugs - Agonist -Antagonist - Factors modifying drug action - Dosage calculations.
UNIT II SYSTEMIC PHARMACOLOGY 9
Mechanism of action - Pharmacology - Acetylcholine - Atropine - Adrenaline - Prazosin -Propranolol - Barbiturates - Benzodiazepine - Chlorpromazine - Imipramine
UNIT III CARDIOVASCULAR PHARMACOLOGY 9
Classification - Mechanism of action - Pharmacology - Digoxin - Glyceryl trinitrate - Verapamil -Clonidine - Hydralazine - Quinidine - Statins
UNIT IV ANTIMICROBIAL PHARMACOLOGY 9
Mode of action - Pharmacology - Sulphonamides - Ciprofloxacin - Penicillin G - Erythromycin -Rifampicin - Amphotericin B - Acyclovir - Chloroquine - Alkylating agents - Paclitaxel
UNIT V PERIPHERAL NERVOUS SYSTEM AND GASTROINTESTINAL PHARMACOLOGY 9
Classification - Mechanism of action - d-Tubocurarine - Succinyl choline - Cimetidine -Metoclopramide - Amoxicillin - Ondansetron - Lactulose.
L: 45 T: 15 Total: 60
TEXT BOOKS
1. Satoskar, R.S., Bhandarkar, S.D., and Rege, N.N., "Pharmacology and Pharmacotherapeutics", Popular Prakashan (P) Ltd., 2006.
2. Tripathi, K.D., "Essentials of Medical Pharmacology", 4th Edition, Jaypee Brothers Medical
Publishers (P) Ltd, 1999.
REFERENCES
1. Hardman, J.G and Limbird, L.E., "Goodman and Gilman's: The Pharmacological Basis of Therapeutics" 10th Edition, Medical Publishing Division, 2001.
2. Lawrence, D.R., Bennett, P.N., and Brown, M.J., "Clinical Pharmacology" 8th Edition, Churchill Livingstone, 1998.
3. Das, M.M., "Pharmacology for Second Professional Students" 5th Edition, Books and Allied
(P) Ltd, 2004.
ENGINEERING THERMODYNAMICS
LT P 4 0 0
UNIT I CONCEPTS AND FIRST LAW OF THERMODYNAMICS 12
Scope - Concepts - Thermodynamic system - State and equilibrium - Process and cycles -Temperature and zeroth law of thermodynamics - Properties of pure substances - First law of thermodynamics - First law analysis of closed systems and control volumes and its application.
UNIT II ENTROPY AND THE SECOND LAW OF THERMODYNAMICS 12
Clausius inequality - Entropy - Causes of entropy change - Entropy change of pure substances -Thermal energy reservoirs - Heat engines - Perpetual motion machines - Reversible and irreversible processes - Carnot cycle and principles - Carnot heat engine - Second law efficiency - Second law analysis of open and closed systems.
UNIT III REFRIGERATION, VAPOR & COMBINED POWER CYCLES 12
Refrigerators and Heat pumps - The Carnot refrigerator and heat pumps - The reversed Carnot cycle
- Ideal and Actual vapor compression Refrigeration cycle - Selection of right refrigerants - Heat pumps - Absorption refrigerator system - The Carnot vapor cycle - Rankine cycle - Cogeneration -Second law analysis of vapor power cycles.
UNIT IV PVT RELATIONS AND THERMODYNAMIC RELATIONS 12
PVT relations for gases and liquids - Equations of state - Cubic equations of state - Thermodynamic properties from equations of state - Compressibility factor - Generalised properties of fluids - Law of corresponding state, acentric factor, gas mixtures - Thermodynamic relations - Maxwell's relations - Estimation of thermodynamic properties - Thermodynamic properties of homogeneous mixtures - Partial molar properties - Fugacity and fugacity coefficients - Lewis and Randall rule -Property changes of mixing, activity - Excess properties - Activity coefficients.
UNIT V PHASE EQUILIBRIA AND CHEMICAL REACTION EQUILIBRIA 12
Phase equilibria - Pure component and mixtures - Van Laar, Margules equation, Group contribution method - Gibb's Duhem equation - Consistency tests - Partially miscible and immiscible systems -Azeotropes - Retrograde condensation - Thermodynamic diagrams -Chemical equilibria - Heat effects, industrial reactions - Free energy calculations - Homogeneous and heterogeneous reactions
- Equilibrium composition.
Total: 60
TEXT BOOKS
1. Smith, J.M and Van Ness., "Introduction to Chemical Engineering Thermodynamics", 5th Edition, McGraw Hill, 1996.
2. Narayanan, K.V., "A Text Book of Chemical Engineering Thermodynamics", Prentice Hall
of India, 2002.
REFERENCES
1. Hougen, O.A, Watson, K.M and Ragatz, R.A., "Chemical Process Principles", Vol. II, CBS
Publishers, 2002.
2. Kyle, B.G., "Chemical and Process Thermodynamics", 2nd Edition, Prentice Hall of India,
2000.
3. Rao, Y.V.C., "Chemical Engineering Thermodynamics", Universities Press, 1997.
CHEMICAL REACTION ENGINEERING
L T P 4 0 0
UNIT I REACTION KINETICS 12
Chemical kinetics - Classification of chemical reactions - Concentration and temperature dependent term of rate equation - Arrhenius collision and transition state theory - Searching for a mechanism.
UNIT II INTERPRETATION OF BATCH REACTOR DATA 12
Integral and differential methods of analysis - Half-life method - Zero order reaction - Empirical rate equation of nth order - Irreversible first and second order reactions for variable and constant volume systems.
UNIT III REACTOR DESIGN 12
Ideal reactors - Batch reactor - Plug flow reactor - Mixed flow reactor - Space time - Space velocity - Performance equations and their graphical representation.
UNIT IV HEAT EFFECTS 12
Temperature and pressure effects on single and multiple reactions - Adiabatic - Non-adiabatic -Isothermal and non-isothermal operations.
UNIT V DESIGN OF REACTOR FOR SINGLE AND MULTIPLE REACTIONS 12
Single reactions - Size comparison of single reactors - Recycle reactor - Auto catalytic reactions -Multiple reactions - Irreversible reactions in series and parallel.
Total: 60
TEXT BOOKS
1. Levenspiel, O., "Chemical Reaction Engineering", 3rd Edition, John Wiley Publications,
1999.
2. Fogler, W., "Chemical Reaction Engineering", 3rd Edition, Prentice Hall of India, 1999.
REFERENCE BOOKS
1. Smith, J.M., "Chemical Engineering Kinetics", 3rd Edition, McGraw Hill, 1981.
2. Dawande, S.D., "Principles of Reaction Engineering", 1st Edition, Central Techno Publications, 2001.
3. Richardson, J.F and Peacock, D.G., "Coulson Richardson - Chemical Engineering", Vol. III, 3rd Edition, Butterworth- Heinemann- Elsevier, 2006.
PROCESS INSTRUMENTATION
LT P 4 0 0
UNIT I PHYSICAL PROPERTY MEASUREMENT 12
Density and specific gravity - Viscosity and consistency - Refractive index analyzers - Boiling point - Flash point analyzers - Thermal conductivity.
UNIT II TEMPERATURE MEASUREMENT 12
Differential expansion and fluid expansion types - Resistance thermometers - Thermoelectric pyrometers - Radiation pyrometers - Optical pyrometers - Pyrometric cones - Ultrasonic thin wire thermometer.
UNIT III PRESSURE MEASUREMENT 12
Absolute pressure - Gauge pressure or vacuum - Liquid types and spring balanced types -Differential pressure - Manometer types - Simple U tube and inclined tube manometer and sealed bell types - Pressure transmitters.
UNIT IV FLOW MEASUREMENT 12
Volumetric meters - Variable head meters - Orifice meter - Venturimeter - Pitot tube - Closed channel and open channel types - Variable area meters - Velocity and current meters - Anemo meter - Ultrasonic flowmeter - Mass meters.
UNIT V LEVEL MEASUREMENT 12
Measurement of head and level - Float methods - Hydrostatic pressure methods - Gauge glass automatic detector - Ultrasonic probe - Electronic level gauge - Continuous capacitance gauge.
Total: 60
TEXT BOOKS
1. Nakra, B.C and Chaudhry, K.K., "Instrumentation, Measurement and Analysis", 2nd Edition, Tata McGraw- Hill, 2004.
2. Singh, S.K., "Industrial Instrumentation and Control", 2nd Edition, Tata McGraw-Hill, 2007.
REFERENCES
1. Doebelin, E.O., "Measurement System Application and Design", 4th Edition, McGraw-Hill, 1998.
2. Patranabis, D., "Principles of Industrial Instrumentation", 2nd Edition, Tata McGraw-Hill,
2007.
3. Sawhney, A.K., "A Course in Electrical, Electronics Measurement and Instrumentation", Dhanpat Rai and Sons, 1999.
PHARMACEUTICAL CHEMISTRY LABORATORY
L T P
0 0 3
1. Determination of percentage purity given drug sample.
2. Estimation of amount of active ingredient present in the given sample.
3. Chromatographic identification of organic compounds.
4. Analysis and identification of functional groups of pharmaceutical substances.
5. Analysis of impurities in fine chemicals / pharmaceutical substances by conventional chemical methods.
6. Official limit tests for impurities in pharmaceutical raw materials.
7. Determination of physical constants - melting point, boiling point, weight per ml, refractive index and viscosity.
8. Purification techniques for bulk drugs.
Total: 45
PHARMACEUTICAL DOSAGE FORMS LABORATORY
L T P 0 0 3
1. Preparation of three official solutions.
2. Preparation of two official syrups.
3. Preparation of three official lotions.
4. Preparation of two official liniments.
5. Preparation of official ointments with different classes of bases.
6. Preparation of two creams.
7. Preparation of two pastes.
8. Preparation of two suspensions.
9. Preparation of two emulsions.
10. Preparation and evaluation of injection.
11. Preparation of granules and effervescent granules.
12. Determination of stability of emulsion.
13. Formulation of two powders.
14. Preparation of microcapsules by solvent evaporation method.
Total: 45
CHEMICAL REACTION ENGINEERING LABORATORY
LT P 0 0 3
1. Determination of reaction rate constant for a saponification reaction in batch reactor.
2. Determination of reaction rate constant for a saponification reaction in plug flow reactor.
3. Determination of reaction rate constant for a saponification reaction in mixed flow reactor.
4. Determination of mean residence time by RTD studies in plug flow reactor.
5. Determination of mean residence time by RTD studies in mixed flow reactor.
Total: 45